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Spectral study of cholesteryl linoleate - amphotericin B interaction and behaviour of cholesteryl esters in electric field

L.E. VÎJAN1,* , C.M. TOPALĂ1, B. OPRESCU1, S. ANGHEL1

Affiliation

  1. University of Piteşti, Faculty of Sciences, Târgu din Vale No.1, Piteşti - 110040, Romania

Abstract

Cholesteryl esters are abundant in biological membranes. Their presence alongside fatty acids, free or bound to phospholipids, modulates the lipid membrane behaviour. This study describes the unfacilitated passive diffusion electric model of some mixtures of cholesteryl linoleate and glycerol in order to explain the nature of relaxation time. Relaxation time responds by equivalent electric capacity of transmembrane process. This time depends on the nature of transported compounds and decreases with their concentration. Also, the purpose of the present work is the study of the interaction between amphotericin B and a cholesteryl ester, namely cholesteryl linoleate.

Keywords

Absorption UV-Vis spectroscopy, Cholesteryl ester (CE), Cholesterol (Ch), Cholesteryl linoleate (Ch-Lin), Amphotericin B (AmB).

Citation

L.E. VÎJAN, C.M. TOPALĂ, B. OPRESCU, S. ANGHEL, Spectral study of cholesteryl linoleate - amphotericin B interaction and behaviour of cholesteryl esters in electric field, Optoelectronics and Advanced Materials - Rapid Communications, 2, 9, September 2008, pp.582-586 (2008).

Submitted at: July 16, 2008

Accepted at: Aug. 28, 2008