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JIANJUN LIU1,* , LANLAN FAN1, YUPING WU1, JINGHUA CHEN1, PU LI1,*
Terahertz (THz) analysis of living cells is a research hotspot in spectroscopy. The key challenge is mitigating water interference to enable sensitive liquid-phase sample detection. This paper presents a high-sensitivity THz microfluidic biosensor using a metamaterial absorber, designed to reduce water absorption and enhance sensitivity. The sensor chip integrates a metamaterial absorber with microfluidic channels, exhibiting two perfect absorption peaks at 0.758 THz and 1.049 THz, with a refractive index sensitivity of up to 548.67 GHz/RIU. Experiments show the sensor maintains high Q-factor and Figure of Merit (FoM). As analytes with different refractive indices flow through the channels, both resonance peaks exhibit distinct red shifts. Material detection is achieved by analyzing the redshift difference between peaks. This metamaterial-based THz microfluidic biosensor shows promise for label-free trace substance detection and offers new directions for THz biomedical research.
THz, Sensors, Detection, Microfluidic.
JIANJUN LIU, LANLAN FAN, YUPING WU, JINGHUA CHEN, PU LI, Research on high-sensitivity metamaterial-based terahertz microfluidic sensors for biological detection, Optoelectronics and Advanced Materials - Rapid Communications, 19, 7-8, July-August 2025, pp.328-336 (2025).
Submitted at: Oct. 6, 2024
Accepted at: Aug. 4, 2025
Optoelectronics and Advanced Materials - Rapid Communications
(2024): Impact Factor = 0.4 - Journal Citation Reports (Clarivate Analytics, 2025)
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