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Remote radio-control of siRNA release from magnetite-hydrogel composite

M. BABINCOVÁ1,* , J. NOVOTNÝ1, J. ROSENECKER2, P. BABINEC3

Affiliation

  1. Institute of Physiotherapy, Balneology and Healing Rehabilitation, University of St. Cyril and Methodius, Rázusová 24, Piešťany, Slovakia
  2. Department of Pediatrics, Ludwig-Maximillians-University, Lindwurmstr. 2a, D-80337 Munich, Germany
  3. Department of Nuclear Physics and Biophysics, Comenius University, Mlynská dolina F1, 842 48 Bratislava, Slovakia

Abstract

Magnetically responsive gel network formed by copolymerization of N-isopropylacrylamide and acrylamide, with a critical solution temperature tuned slightly above the body temperature, containing embedded magnetic nanoparticles was prepared. Magnetic nanoparticles were used for the gel heating when exposed to radiofrequency field with frequency 760 KHz. When the temperature of the copolymer exceeded the critical solution temperature, the material collapsed and a fast release of small interefering RNA co-embedded inside the gel network was observed, which may have far reaching therapeutic implications.

Keywords

Superparamagnetic hydrogel, Radiofrequency field, Gene therapy, siRNA controlled release.

Citation

M. BABINCOVÁ, J. NOVOTNÝ, J. ROSENECKER, P. BABINEC, Remote radio-control of siRNA release from magnetite-hydrogel composite, Optoelectronics and Advanced Materials - Rapid Communications, 1, 11, November 2007, pp.644-647 (2007).

Submitted at: Sept. 4, 2007

Accepted at: Oct. 31, 2007