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C. POPA1,* , C. MATEI1
In this work, a CO2 laser photoacoustic spectroscopy (LPAS) system was used to detect and monitor traces of ethylene in human breath air resulting from oxidative stress following the radiotherapy and dialysis treatment at patients affected by cancer and patients with renal failure, respectively. The LPAS proved to be a very sensitive and selective gas detection technique. Ethylene is well established as a breath biomarker for free radical induced oxidative stress and cell degradation. Furthermore, anti-tumour radiotherapy and renal dialysis are known to induce the oxidative attack, and our measurements may offer insight into the nature of this assault. We have found out that patients affected by cancer, treated by external radiotherapy and patients affected by renal failure, treated by standard dialysis, suffer increased generation of oxidants. Breath samples were collected before and immediately after treatment. The levels of ethylene in breath samples were measured at 10P (14) CO2 laser line (where the ethylene absorption coefficient has the largest value of 30.4 cm-1atm-1), and compared with breath air contents from healthy humans. Monitoring of breath ethylene may provide guidance for optimal therapy and prevention of abnormality in patients on long-term radiotherapy or hemodialysis therapy..
Laser photoacoustic spectroscopy, Ethylene detection, Oxidative attack, Radiotherapy, Dialysis treatment.
C. POPA, C. MATEI, Photoacoustic assessment of oxidative stress in dialysis and radiotherapy by LPAS system, Optoelectronics and Advanced Materials - Rapid Communications, 5, 11, November 2011, pp.1237-1242 (2011).
Submitted at: Oct. 18, 2011
Accepted at: Nov. 23, 2011
Optoelectronics and Advanced Materials - Rapid Communications
(2022): 0.5 - 2022 Journal Citation Reports (Clarivate Analytics, 2023)
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