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Noncovalent immobilization of collagen on the surface of silanized hydroxyapatite

M. OLARU1,* , B. C. SIMIONESCU2, C. COTOFANA1, X. PATRAS3

Affiliation

  1. ”Petru Poni” Institute of Macromolecular Chemistry”, 41A Gr. Ghica Voda Alley, 700487 Iasi, Romania
  2. Department of Natural and Synthetic Polymers,”Gh. Asachi” Technical University, 53A Dimitrie Mangeron Blv., 700050 Iasi, Romania
  3. ”Petre Andrei” University, Department of Pharmacology, 13 Gh. Voda Str., 700400 Iasi, Romania

Abstract

The aim of this study was to synthesize and characterize a hybrid composite based on type I hydrated collagen, hydroxyapatite and a silane precursor (amino-propyltriethoxysilane). Through sol-gel approach of the precursor and noncovalent immobilization of collagen on the surface of hydroxyapatite, a new type of hybrid material was obtained in which microspheres comprising silica and hydroxyapatite particles are dispersed in an oriented fibrous network of collagen fibrils. Moreover, the sol-gel reactions between the above-mentioned components were not accompanied by conformational changes of the adsorbed collagen, thus preserving its secondary structure.

Keywords

Collagen, Hydroxyapatite, Sol gel, Method, Silanized surface.

Citation

M. OLARU, B. C. SIMIONESCU, C. COTOFANA, X. PATRAS, Noncovalent immobilization of collagen on the surface of silanized hydroxyapatite, Optoelectronics and Advanced Materials - Rapid Communications, 2, 11, November 2008, pp.726-729 (2008).

Submitted at: Oct. 1, 2008

Accepted at: Oct. 30, 2008