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K. ULUBAYRAM1,* , Y. TUNC, E. BAYKARA1
Feasibility of molecularly imprinted polymeric microspheres (MIPs) has been investigated for colonic delivery of 5- aminosalicylic acid (5-ASA). 5-ASA imprinted microspheres were prepared by a single step precipitation polymerization of 2-(diethylamino) ethyl methacrylate (DEAEMA; functional monomer) and trimethylolpropane trimethacrylate (TRIM; crosslinker). The release profiles of 5-ASA imprinted and non-imprinted microspheres were evaluated. We present a precipitation polymerization method for preparing uniform molecularly imprinted microspheres in micron range, quickly and cleanly. Monodisperse polymer particles with good spherical shapes and smooth surfaces were obtained. Furthermore, the imprinted microspheres have a slower 5-ASA release in the initial stages than the non-imprinted microspheres, because of the interaction of the drug molecules with the recognition sites in the imprinted microspheres. This result showed that molecular imprinting may have a potential for controlled delivery of drugs.
Molecular imprinting, Colonic delivery, 5-aminosalicylic acid, Precipitation polymerization, Microspheres, 2-(diethylamino) ethyl methacrylate, Trimethylolpropane trimethacrylate.
K. ULUBAYRAM, Y. TUNC, E. BAYKARA, Molecularly imprinted acrylic-based microspheres for colonic delivery of 5-aminosalicylic acid, Optoelectronics and Advanced Materials - Rapid Communications, 1, 6, June 2007, pp.312-316 (2007).
Submitted at: March 12, 2007
Accepted at: April 25, 2007
Optoelectronics and Advanced Materials - Rapid Communications
(2024): Impact Factor = 0.4 - Journal Citation Reports (Clarivate Analytics, 2025)
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