"

Cookies ussage consent

I agree.

Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our site without changing the browser settings you grant us permission to store that information on your device.

In vivo tensile tests of biomimetic titanium implants pulsed laser coated with nanostructured Calcium Phosphate thin films

I. N. MIHAILESCU1,* , S. LAMOLLE2, G. SOCOL1, F. MIROIU1, H.J. ROENOLD2, A. BIGI3, I. MAYER4, F. CUISINIER5, S.P. LYNGSTADAAS2

Affiliation

  1. Laser Department, National Institute for Lasers, Plasma and Radiation Physics, 77125 Magurele Ilfov, Romania
  2. Department of Biomaterials, Faculty of Dentistry, University of Oslo, NO-0317 Oslo, Norway
  3. Department of Chemistry ‘‘G. Ciamician’’, University of Bologna, 40126 Bologna, Italy
  4. Department of Inorganic and Analytical Chemistry, Hebrew University of Jerusalem, 91904 Jerusalem, Israel
  5. Biologie Santé-Nanoscience, Faculty of Dentistry, University of Montpellier 1, 545 Jean-Louis Viala Av., 34193 Montpellier, France

Abstract

Bioactive titanium coatings made of commercial hydroxyapatite, Mn2+-doped carbonated hydroxyapatite, and octacalcium phosphate were obtained by pulsed laser deposition. The functionalized biomimetic titanium implants coated with nanostructured calcium phosphate layers were successfully tested in vivo. Eight weeks after implantation in the tibia bones of 6-month-old New Zealand White female rabbits the attachment between bone and implants was tested in a tensile (pullout) test. The pullout force was found to more than double in the case of CaP-coated Ti coins, compared with the uncoated ones. Furthermore, compared with the commercial HA-coated implants, the pullout force increased by 25% in implants with Mn2+-doped carbonated hydroxyapatite, and 10% in octacalcium phosphate-coated implants. The results suggest that nanostructured CaP deposition has a significant potential for improving the performance of titanium implants in bone, and that the composition and structure of the calcium phosphate coating have a significant influence on their biological effect.

Keywords

In-vivo test, Bone implants, Calcium phosphate coatings, Osseointegration, Pulsed laser deposition.

Citation

I. N. MIHAILESCU, S. LAMOLLE, G. SOCOL, F. MIROIU, H.J. ROENOLD, A. BIGI, I. MAYER, F. CUISINIER, S.P. LYNGSTADAAS, In vivo tensile tests of biomimetic titanium implants pulsed laser coated with nanostructured Calcium Phosphate thin films, Optoelectronics and Advanced Materials - Rapid Communications, 2, 6, June 2008, pp.337-341 (2008).

Submitted at: May 12, 2008

Accepted at: June 5, 2008