Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our site without changing the browser settings you grant us permission to store that information on your device.
E. G. BORISOVA1,* , P. P. TROYANOVA2, L. A. AVRAMOV1
Many optical techniques are applied recently in clinical practice for obtaining of qualitatively and quantitatively new data from the lesions investigated. Due to their high sensitivity in detection of small changes, spectroscopy techniques are widely used for detection of early changes in biological tissues. One of the most promising approaches is fluorescence detection of normal and abnormal tissues using naturally existing fluorescent molecules (autofluorescence) or added fluorescent markers (exogenous fluorescence). In current study are presented results obtained from autofluorescence detection of a number of benign and malignant cutaneous pigmented lesions. As an excitation source a nitrogen laser at 337 nm is applied and a microspectrometer detects signals from human skin in vivo. The main spectral features of benign lesions – base-cell papilloma, compound nevus, heamangioma, dysplastic nevi and malignant lesions – base-cell carcinoma and malignant melanoma are discussed and their possible origins are indicated. Differentiation between benign and malignant forms using detected fluorescent spectra is proposed. Results obtained could be used for development of more complete picture of fluorescent properties of these widely spread skin disorders, as well as to be introduced in clinical algorithms for early detection and differentiation between benign/ dysplastic/ malignant skin lesions.
Autofluorescence, Nitrogen laser, Skin cancer.
E. G. BORISOVA, P. P. TROYANOVA, L. A. AVRAMOV, Fluorescence spectroscopy for early detection and differentiation of cutaneous pigmented lesions, Optoelectronics and Advanced Materials - Rapid Communications, 1, 8, August 2007, pp.388-393 (2007).
Submitted at: March 15, 2007
Accepted at: July 8, 2007
Optoelectronics and Advanced Materials - Rapid Communications
(2024): Impact Factor = 0.4 - Journal Citation Reports (Clarivate Analytics, 2025)
Active accounts were imported to the new platform and assigned a random password by default. In order to access your account you need to access the login page and go through the Lost Password dialog (involves the system sending you an email with instructions) in order to reset your password. This step is necessary as passwords are kept in hashed form and the new platform uses modern hashing algorithms incompatible with the previous ones.