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Cerenkov luminescence imaging (CLI), a promising technique to image medical radionuclides, suffers extremely low intensity level and strong attenuation of tissues, making it difficult to apply in clinic. Inspired by radioluminescence phenomenon, we propose an optical way to detect medical radionuclides, named the radioluminescence film imaging (RLFI). With the help of lab-produced film made of radioluminescence microparticles, our RLFI technology enables detection of radionuclides in a living body at a depth much deeper than current CLI method, having great potential applications in preclinical and clinical studies. We first validated the feasibility of our RLFI technology by characterizing the concentration and depth dependency of RLFI signal, and then explored its potential by in vivo imaging of radionuclide metabolism in mice..
Cerenkov luminescence imaging, Radioluminescence film, Radioluminescence film imaging, Radioluminescence microparticles, In vivo imaging, Optical imaging, Radionuclides.
LIN WANG, XIN CAO, XU CAO, FEI KANG, YONGHUA ZHAN, XIAOWEI HE, JING WANG, XUELI CHEN, Feasibility study of radioluminescence film imaging: an optical way to detect medical radionuclides, Optoelectronics and Advanced Materials - Rapid Communications, 12, 9-10, September-October 2018, pp.542-546 (2018).
Submitted at: Dec. 25, 2017
Accepted at: Oct. 10, 2018