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Effects of piroxicam and meloxicam complexes of Co (II), Ni(II), Cu(II) and Zn(II) as inhibitors of cyclooxygenase-2 determined by Molecular docking

A. BETERINGHE1,*

Affiliation

  1. Institute of Physical Chemistry of the Romanian Academy, Laboratory of Coordination and Supramolecular Chemistry, Splaiul Independentei 202, Bucharest, 060021, Romania

Abstract

Was achieved a study involving Molecular docking method for selection of piroxicam and meloxicam complexes of Co (II), Ni(II), Cu(II) and Zn(II) as inhibitors of cyclooxygenase-2 (COX-2). [Co(HMel)2(H2O)2] – COX-2 complex with the lowest total energy (-1616.2 KJ/mol) was selected as a possible inhibitor of COX-2..

Keywords

COX-2, Molecular Docking, Complexes, Piroxicam, Meloxicam.

Citation

A. BETERINGHE, Effects of piroxicam and meloxicam complexes of Co (II), Ni(II), Cu(II) and Zn(II) as inhibitors of cyclooxygenase-2 determined by Molecular docking, Optoelectronics and Advanced Materials - Rapid Communications, 9, 11-12, November-December 2015, pp.1527-1529 (2015).

Submitted at: Sept. 6, 2015

Accepted at: Oct. 28, 2015