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S. SHARMA1, M. C. SHARMA2,*
The simple, accurate, precise and sensitive methods for Atorvastatin calcium and Pioglitazone HCl have been developed using atomic absorption spectrometer. We are new developed method with Disodium Edetate Calcium solution and Sodium chloride solution in the pharmaceutical preparation.These methods are based on reaction of both the drugs with Disodium Edetate Calcium solution and Sodium chloride to give purssion pink colour and violet colour metal complexes respectively. These complexes are readily extracted with chloroform and estimated via determination of copper and cobalt content in the formed complexes after digestion with 1.0 M sulphuric acid by atomic absorption spectrometer. Atorvastatin calcium and Pioglitazone HCl can be determined in the concentration ranges 1.5-15.0 and 2.0-34.0 μgml-1 with mean percentage recovery 99.98 ± 1.12 and 100.0 ± 0.24% respectively. In sodium chloride; Atorvastatin calcium and Pioglitazone HCl can e measured in the concentration ranges 4.0-19.5 and 3.5-21.0 μg ml-1 with mean percentage recovery 101.01 0.09 and 100.05 ± 0.08 % respectively.
Atomic absorption spectrometry (AAS), Atorvastatin calcium and Pioglitazone HCl, Disodium Edetate Calcium solution and Sodium chloride.
S. SHARMA, M. C. SHARMA, Determination of atorvastatin calcium and pioglitazone HCl in pharmaceutical formulations form by using atomic absorption spectrometry, Optoelectronics and Advanced Materials - Rapid Communications, 4, 8, August 2010, pp.1196-1199 (2010).
Submitted at: July 4, 2010
Accepted at: Aug. 12, 2010
Optoelectronics and Advanced Materials - Rapid Communications
(2023): 0.5 - 2023 Journal Citation Reports (Clarivate Analytics, 2024)
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