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M. OLARU1,* , C. COTOFANA1, X. PATRAS2
The aim of this study was to synthesize and characterize a new poly(vinyl alcohol) (PVA) hybrid composite with a basic drug content, e.g., 2-[4-(2-methylpropyl)phenyl]propanoic acid (ibuprofen). Through sol-gel approach of the polymeric matrix (chloro-propyltriethoxysilane) with a PVA precursor that contains a fluorescent dye (lissamine rhodamine-B sulphonyl chloride), a new kind of hybrid material was obtained in which clusters of micrometric dimensions were dispersed in PVA organic matrix. The incorporation of ibuprofen within sol-gel derived matrix is expected to lead to compounds that allow a sustained and controlled release of the drug.
Poly(vinyl alcohol), Ibuprofen, Sol gel, Drug delibery.
M. OLARU, C. COTOFANA, X. PATRAS, Design of novel PVA-based hybrid composites for drug delivery, Optoelectronics and Advanced Materials - Rapid Communications, 3, 12, December 2009, pp.1273-1275 (2009).
Submitted at: Nov. 2, 2009
Accepted at: Nov. 23, 2009
Optoelectronics and Advanced Materials - Rapid Communications
(2023): 0.5 - 2023 Journal Citation Reports (Clarivate Analytics, 2024)
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