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AKRAM VALIPOOR1,* , KAZEM PARIVAR2, MEHRDAD MODARESI3, GHOLAM REZA AMIR4, MANOOCHEHR MESSRIPOUR3
Background: There are many promising progresses in biological diagnosis and using quantum dots in nanostructures and multipurpose tools. Nevertheless, in vivo cytotoxicity of these nanoparticles has not been highly considered. For this reason, the cytotoxic effects of CdSe quantum dots on testis development before maturity are presented in this study. Materials and Methods: In this work, 10, 20 and 40 mg/kg doses of CdSe quantum dots were injected to some one month old male mice. Structural and optical properties of quantum dots were studied by XRD, UV-Vis absorption spectrum and Scanning Tunneling Microscopy and the number of cells in seminiferous tubes of various groups were analyzed using SPSS 16 programme (one way Anova test). Results: Histological studies of testis tissue showed a high toxicity of CdSe in 40 mg/kg dose followed by a decrease in lamina propria, destruction in interstitial tissue, deformation of seminiferous tubes, and reduction in number of spermatogonia, spermatocytes, spermatides, and matured sperms. Although histological study of epididymis tissue showed no significant effect of quantum dots on morphology and structure of tube and its covering epithelium there was a considerable reduction in the lumen content. Conclusion: This study showed a high toxicity of CdSe quantum dots on development of testis tissue, even in lower doses and considering lack of literature review in this field, this study can be an introduction to researches of toxicity effect of quantum dots on development of male reproduction system..
CdSe, Quantum dots, Testis development, Cytotoxicity.
AKRAM VALIPOOR, KAZEM PARIVAR, MEHRDAD MODARESI, GHOLAM REZA AMIR, MANOOCHEHR MESSRIPOUR, Cytotoxicity effects of CdSe quantum dots on testis development of laboratory mice, Optoelectronics and Advanced Materials - Rapid Communications, 7, 3-4, March-April 2013, pp.252-257 (2013).
Submitted at: Oct. 30, 2012
Accepted at: April 11, 2013
Optoelectronics and Advanced Materials - Rapid Communications
(2022): 0.5 - 2022 Journal Citation Reports (Clarivate Analytics, 2023)
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